Ongoing EU Clinical Trials

ESVONC attaches great importance to innovation and evidence-based medicine in the field of veterinary oncology. Therefore, we are happy to share with you with a monthly overview of ongoing canine oncology trials in Europe. We are convinced that knowledge of these trials will enhance collaboration between researchers and clinicians, thus increasing recruitment for clinical trials and treatment options for dogs.

Please find below a non-exhaustive listing of ongoing trials as gathered in the Oncowaf database. For more details about these trials, please visit https://oncowaf.be/en/ClinicalTrials.

If you have an ongoing clinical trial and would like to add it to the Oncowaf clinical trial database and this mailing, please contact contact@oncowaf.com. This list is an intiative of dr. Laetitia Cicchelero (DVM, PhD, Cross-health coordinator @ Faculty of Veterinary Medicine, Ghent University). Laetitia is initiator and inspirer of ONCOWAF. ESVONC wishes to thank Laetitia for her efforts to create this useful overview.

This list is updated on a monthly basis.
(green: new trial, orange: trial enters its last month of recruitment).

Country Requested tumour types for clinical trial Type of trial  
Belgium Head & Neck tumours Fluorescence-guided surgery Hilde de Rooster
Nayra Valle
 

Osteosarcoma, chondrosarcoma, benign osteolytic lesions

Percutaneous cementoplasty

Stella Minnoye

  Transitional cell carcinoma - bladder Characterisation of biomarkers and immune response to improve diagnosis, prognosis and treatment

Annick Hamaide

  B cell lymphoma Sample collection to study lymphoma and optimize its approach

Anna Blockeel

  All tumour types Cardiac ultrasound to explore the effects of chemotherapy on the heart (diagnostic trial) Gitte Mampaey
  All tumour types Novel imaging system to improve intra-operative cancer margin assessment: Fluorescence Lifetime Imaging Simone Jansen 
 France Urothelial carcinoma Focused ultrasound anti-cancer treatment at high intensity: evaluation of tolerance and efficacy Gabriel Chamel
  Easily reachable carcinoma and/or liver carcinoma and/or carcinomic liver metastases Immunotherapy Telomium
  Metastatic carcinoma Assessing safety and efficacy of medical device capturing circulating tumour cells OCRvet
  Oral malignant melanoma, oral SCC  Intra-tumoral immunotherapy VetAgro Sup 
Italy All tumour types Aspartame for the prevention of chemotherapy-induced diarrhoea Paola Valenti
Portugal Hepatic neoplasia Thermoablation by microwaves or radiofrequency Joaquim Henriques
  Chemodectoma Microwave ablation Joaquim Henriques
Spain All tumour types Aspartame for the prevention of chemotherapy-induced diarrhoea Juan Borrego
  B cell lymphoma Evaluation of circulating tumour cells (diagnostic trial)


Victor Domingo Roa

Sweden

Hematological cancers (lymphoma, leukemia)

Treatment with a transcription inhibitor 

Mia Hedlund

Switzerland Sinonasal tumours Heterogenous dose treatment radiotherapy Carla Bley
  High-grade glioma Chemoradiation for high-grade glioma Carla Bley
  Peripheral nerve sheath tumour of the brachial or lumbar plexus Fluorescence-guided surgery Mirja Nolff
  Soft tissue sarcoma Fluorescence-guided surgery Mirja Nolff
  Soft tissue and bone sarcomas Improve the detection and classification of sarcomas using new PET tracers Mirja Nolff
The Netherlands Metastatic or recurrent insulinoma Prospective evaluation of palliative and adjuvant toceranib phosphate therapy Floryne Buishand
  Pheochromocytoma Study and sample collection of pheochromoctomas to allow development of therapy for inoperable tumours  Utrecht University 
  Histocytic sarcoma  Study and sample collection of Flatcoated retrievers to study histiocytic sarcoma and develop DNA test  Utrecht University
  Osteosarcoma Viral Therapy  Utrecht University
  TCC of the bladder neck, prostate cancer  Cancer vaccine (immunotherapy) Arno Roos
Lobke van Bergen
United Kingdom Metastatic or recurrent insulinoma Prospective evaluation of palliative and adjuvant toceranib phosphate therapy Floryne Buishand
  All tumour types Aspartame for the prevention of chemotherapy-induced diarrhoea

Aura Veterinary

University of Edinburgh

  Oral melanoma Immunotherapy for dogs with oral melanoma – tigilanol tiglate Kelly Blacklock
  All tumour types Validation of canine oncology-proxy reported outcome measure to support symptom management and quality of life in dogs undergoing chemotherapy Aura Veterinary


ESVONC does not endorse any of the clinical studies listed above, and expressly disclaims any responsibility or liability for any of the content related to these studies. The use of the ESVONC listing for the purpose of recruitment can, however, be acknowledged in the material and methods of these studies.